1. Clustering of Cases of IDDM 2 to 4 Years after Hepatitis B Immunization is Consistent with Clustering after Infections and Progression to IDDM in Autoantibody Positive Individuals
Abstract
“Previous studies demonstrated clusters of cases of IDDM occurring 24 to 48 months after immunization with the hemophilus, pertussis and combined measles mumps rubella vaccines. Data was analyzed to determine if similar clustering of cases of IDDM occurred after immunization with the hepatitis B vaccine. Methods: Data on the incidence of IDDM from hepatitis B immunized and unimmunized cohorts of children was analyzed for the presence of clusters occurring after hepatitis B immunization. Results: Data from Italy, France, and New Zealand indicated rises in the incidence of IDDM occurred between 24 to 48 months after the introduction of the hepatitis B immunization in young children. Conclusion: Several different vaccines as well as infections with natural mumps virus are followed by clusters of cases of IDDM that occur about 24 to 48 months after immunization. This suggests a similar mechanism of action, possibly the triggering of a progressive autoimmune phenomenon.”
Links
https://benthamopen.com/ABSTRACT/TOPEDJ-2-1
Citation
Classen, John Barthelow. "Clustering of Cases of IDDM 2 to 4 Years after Hepatitis B Immunization Is Consistent with Clustering after Infections and Progression to IDDM in Autoantibody Positive Individuals." The Open Pediatric Medicine Journal 2.1 (2008): 1-6.
“Previous studies demonstrated clusters of cases of IDDM occurring 24 to 48 months after immunization with the hemophilus, pertussis and combined measles mumps rubella vaccines. Data was analyzed to determine if similar clustering of cases of IDDM occurred after immunization with the hepatitis B vaccine. Methods: Data on the incidence of IDDM from hepatitis B immunized and unimmunized cohorts of children was analyzed for the presence of clusters occurring after hepatitis B immunization. Results: Data from Italy, France, and New Zealand indicated rises in the incidence of IDDM occurred between 24 to 48 months after the introduction of the hepatitis B immunization in young children. Conclusion: Several different vaccines as well as infections with natural mumps virus are followed by clusters of cases of IDDM that occur about 24 to 48 months after immunization. This suggests a similar mechanism of action, possibly the triggering of a progressive autoimmune phenomenon.”
Links
https://benthamopen.com/ABSTRACT/TOPEDJ-2-1
Citation
Classen, John Barthelow. "Clustering of Cases of IDDM 2 to 4 Years after Hepatitis B Immunization Is Consistent with Clustering after Infections and Progression to IDDM in Autoantibody Positive Individuals." The Open Pediatric Medicine Journal 2.1 (2008): 1-6.
2. Clustering of Cases of Insulin Dependent Diabetes (IDDM) Occurring Three Years After Hemophilus Influenza B (HiB) Immunization Support Causal Relationship Between Immunization and IDDM
Abstract
“Objective:
The hemophilus vaccine has been linked to the development of autoimmune type 1 diabetes, insulin dependent diabetes (IDDM) in ecological studies.
Methods:
We attempted to determine if the Hemophilus influenza B (HiB) vaccine was associated with an increased risk of IDDM by looking for clusters of cases of IDDM using data from a large clinical trial. All children bom in Finland between October 1st, 1985 and August 31st, 1987, approximately 116,000 were randomized to receive 4 doses of the HiB vaccine (PPR-D, Connaught) starting at 3 months of life or one dose starting after 24 months of life. A control-cohort included all 128,500 children bom in Finland in the 24 months prior to the HiB vaccine study. Non-obese diabetic prone (NOD) mice were immunized with a hemophilus vaccine to determine if immunization increased the risk of IDDM.
Results:
The difference in cumulative incidence between those receiving 4 doses and those receiving 0 doses is 54 cases of IDDM/100,000 (P = 0.026) at 7 years, (relative dsk = 1.26). Most of the extra cases of IDDM appeared in statistically significant clusters that occurred in periods starting approximately 38 months after immunization and lasting approximately 6-8 months. Immunization with pédiatrie vaccines increased the risk of insulin diabetes in NOD mice.
Conclusion:
Exposure to HiB immunization is associated with an increased risk of IDDM. NOD mice can be used as an animal model of vaccine induced diabetes.”
Links
https://www.ncbi.nlm.nih.gov/pubmed/12482192
Citation
Classen, John Barthelow, and David C. Classen. "Clustering of Cases of Insulin Dependent Diabetes (IDDM) Occurring Three Years After Hemophilus Influenza B (HiB) Immunization Support Causal Relationship Between Immunization and IDDM." Autoimmunity 35.4 (2002): 247-53.
“Objective:
The hemophilus vaccine has been linked to the development of autoimmune type 1 diabetes, insulin dependent diabetes (IDDM) in ecological studies.
Methods:
We attempted to determine if the Hemophilus influenza B (HiB) vaccine was associated with an increased risk of IDDM by looking for clusters of cases of IDDM using data from a large clinical trial. All children bom in Finland between October 1st, 1985 and August 31st, 1987, approximately 116,000 were randomized to receive 4 doses of the HiB vaccine (PPR-D, Connaught) starting at 3 months of life or one dose starting after 24 months of life. A control-cohort included all 128,500 children bom in Finland in the 24 months prior to the HiB vaccine study. Non-obese diabetic prone (NOD) mice were immunized with a hemophilus vaccine to determine if immunization increased the risk of IDDM.
Results:
The difference in cumulative incidence between those receiving 4 doses and those receiving 0 doses is 54 cases of IDDM/100,000 (P = 0.026) at 7 years, (relative dsk = 1.26). Most of the extra cases of IDDM appeared in statistically significant clusters that occurred in periods starting approximately 38 months after immunization and lasting approximately 6-8 months. Immunization with pédiatrie vaccines increased the risk of insulin diabetes in NOD mice.
Conclusion:
Exposure to HiB immunization is associated with an increased risk of IDDM. NOD mice can be used as an animal model of vaccine induced diabetes.”
Links
https://www.ncbi.nlm.nih.gov/pubmed/12482192
Citation
Classen, John Barthelow, and David C. Classen. "Clustering of Cases of Insulin Dependent Diabetes (IDDM) Occurring Three Years After Hemophilus Influenza B (HiB) Immunization Support Causal Relationship Between Immunization and IDDM." Autoimmunity 35.4 (2002): 247-53.
3. Prevalence of Autism is Positively Associated with the Incidence of Type 1 Diabetes, but Negatively Associated with the Incidence of Type 2 Diabetes, Implication for the Etiology of the Autism Epidemic
Abstract
“Background:
Epidemics of type 1 diabetes had been linked to inflammation. Previous reports have suggested the prevalence of autism is increased in patients with type 1diabetes.
Methods:
Medline and Google searches were performed in late 2010 to find a country where there was simultaneous data on the incidence or prevalence of type 1 diabetes, type 2 diabetes and autism in multiple different races. The association between prevalence of autism in children and the incidence of type 1 diabetes or type 2 diabetes in children, when stratified by race, was studied.
Results:
The prevalence of autism has a statistically significant positive association with the incidence of type 1 diabetes but has a statistically significant inverse association with type 2 diabetes.
Conclusion:
This suggests that patients with autoimmune autism likely represent a large subset of patients with autism and that the etiology of the epidemic of autoimmune/inflammation mediated autism in children is likely to be related to the etiology of the simultaneous epidemic of type 1 diabetes in children.”
Links
https://www.omicsonline.org/scientific-reports/2155-9899-SR-679.pdf
Citation
Speakman, John R., and Sahar Heidari-Bakavoli. "Type 2 Diabetes, but Not Obesity, Prevalence Is Positively Associated with Ambient Temperature." Scientific Reports 6 (2016): 30409.
“Background:
Epidemics of type 1 diabetes had been linked to inflammation. Previous reports have suggested the prevalence of autism is increased in patients with type 1diabetes.
Methods:
Medline and Google searches were performed in late 2010 to find a country where there was simultaneous data on the incidence or prevalence of type 1 diabetes, type 2 diabetes and autism in multiple different races. The association between prevalence of autism in children and the incidence of type 1 diabetes or type 2 diabetes in children, when stratified by race, was studied.
Results:
The prevalence of autism has a statistically significant positive association with the incidence of type 1 diabetes but has a statistically significant inverse association with type 2 diabetes.
Conclusion:
This suggests that patients with autoimmune autism likely represent a large subset of patients with autism and that the etiology of the epidemic of autoimmune/inflammation mediated autism in children is likely to be related to the etiology of the simultaneous epidemic of type 1 diabetes in children.”
Links
https://www.omicsonline.org/scientific-reports/2155-9899-SR-679.pdf
Citation
Speakman, John R., and Sahar Heidari-Bakavoli. "Type 2 Diabetes, but Not Obesity, Prevalence Is Positively Associated with Ambient Temperature." Scientific Reports 6 (2016): 30409.
4. Risk of Vaccine Induced Diabetes in Children with a Family History of Type 1 Diabetes
Abstract
“Cohort data from Denmark in all children born from January 1, 1990 to December 31, 2000 was analyzed to assess the association between immunization and type 1 diabetes in all Danish children and in a subgroup where children had a sibling with type 1 diabetes. Pediatric vaccines were associated with a statistically significant increased risk of type 1 diabetes in 12 of 21 endpoints in the general population. The rate ratios in children who received at least one dose of a specific vaccine were also elevated in the subgroup and were statistically the same as in the general population. Three doses of the hemophilus vaccine were associated with a rate ratio of 1.23 (1.02<<RR<<<RR<)”
Links
https://benthamopen.com/contents/pdf/TOPEDJ/TOPEDJ-2-7.pdf
Citation
Classen, John Barthelow. "Risk of Vaccine Induced Diabetes in Children with a Family History of Type 1 Diabetes." The Open Pediatric Medicine Journal 2.1 (2008): 7-10.
“Cohort data from Denmark in all children born from January 1, 1990 to December 31, 2000 was analyzed to assess the association between immunization and type 1 diabetes in all Danish children and in a subgroup where children had a sibling with type 1 diabetes. Pediatric vaccines were associated with a statistically significant increased risk of type 1 diabetes in 12 of 21 endpoints in the general population. The rate ratios in children who received at least one dose of a specific vaccine were also elevated in the subgroup and were statistically the same as in the general population. Three doses of the hemophilus vaccine were associated with a rate ratio of 1.23 (1.02<<RR<<<RR<)”
Links
https://benthamopen.com/contents/pdf/TOPEDJ/TOPEDJ-2-7.pdf
Citation
Classen, John Barthelow. "Risk of Vaccine Induced Diabetes in Children with a Family History of Type 1 Diabetes." The Open Pediatric Medicine Journal 2.1 (2008): 7-10.
5. Type 1 Diabetes Versus Type 2 Diabetes/Metabolic Syndrome, Opposite Extremes of an Immune Spectrum Disorder Induced by Vaccines
Abstract
“There is an epidemic in children of type 2 diabetes and metabolic syndrome including individual diseases that form the components of metabolic syndrome. The epidemic resembles the epidemic of type 1 diabetes in children which has been linked to immunization. The epidemic of obesity in US children has a statistically significant positive correlation with the number of vaccine doses recommended. There is a similar trend with both hypertension and metabolic syndrome. The incidence of type 2 diabetes in Japanese children decreased significantly following the discontinuation of the BCG vaccine, a vaccine which is associated with an increased risk of type 1 diabetes. This paper describes two aberrant responses to immunization. At one extreme immunization leads to progressive autoimmune diseases including type 1 diabetes. A second response to immunization, and an opposite extreme to autoimmunity, is for the body to suppress the immune system through increased cortisol activity and other counter measures leading to type 2 diabetes and metabolic syndrome. Some vaccine recipients may have a mixed response, falling between the extremes, such as an incomplete autoimmune disorder or an intermittent autoimmune disorder. The propensity to develop a particular response relates to race. Japanese children produce large amounts of cortisol following immunization and have lower risk of type 1 diabetes but higher risk of type 2 diabetes than White children. Analysis using Austin Bradford-Hill criteria for causation support a causal relation between immunization and metabolic syndrome. Additional studies are needed to further characterize this risk.”
Links
https://benthamopen.com/ABSTRACT/TOEJ-2-9
Citation
Classen, John Barthelow. "Type 1 Diabetes Versus Type 2 Diabetes/Metabolic Syndrome, Opposite Extremes of an Immune Spectrum Disorder Induced by Vaccines." The Open Endocrinology Journal 2.1 (2008): 9-15.
“There is an epidemic in children of type 2 diabetes and metabolic syndrome including individual diseases that form the components of metabolic syndrome. The epidemic resembles the epidemic of type 1 diabetes in children which has been linked to immunization. The epidemic of obesity in US children has a statistically significant positive correlation with the number of vaccine doses recommended. There is a similar trend with both hypertension and metabolic syndrome. The incidence of type 2 diabetes in Japanese children decreased significantly following the discontinuation of the BCG vaccine, a vaccine which is associated with an increased risk of type 1 diabetes. This paper describes two aberrant responses to immunization. At one extreme immunization leads to progressive autoimmune diseases including type 1 diabetes. A second response to immunization, and an opposite extreme to autoimmunity, is for the body to suppress the immune system through increased cortisol activity and other counter measures leading to type 2 diabetes and metabolic syndrome. Some vaccine recipients may have a mixed response, falling between the extremes, such as an incomplete autoimmune disorder or an intermittent autoimmune disorder. The propensity to develop a particular response relates to race. Japanese children produce large amounts of cortisol following immunization and have lower risk of type 1 diabetes but higher risk of type 2 diabetes than White children. Analysis using Austin Bradford-Hill criteria for causation support a causal relation between immunization and metabolic syndrome. Additional studies are needed to further characterize this risk.”
Links
https://benthamopen.com/ABSTRACT/TOEJ-2-9
Citation
Classen, John Barthelow. "Type 1 Diabetes Versus Type 2 Diabetes/Metabolic Syndrome, Opposite Extremes of an Immune Spectrum Disorder Induced by Vaccines." The Open Endocrinology Journal 2.1 (2008): 9-15.
6. Vaccines and the risk of insulin-dependent diabetes (IDDM): potential mechanism of action
Abstract
“Immunization with a number of different vaccines, including live and killed vaccines, has been linked to the development of insulin-dependent (type 1) diabetes in humans and animals. Multiple different mechanisms have been proposed to explain the association between vaccines and diabetes. The current paper reviews multiple different mechanisms by which vaccines are known to manipulate the immune system and can induce an autoimmune disease such as type 1 diabetes. Genetic variability may determine which of these pathways, or possible other pathways, predominate in an individual following immunization.”
Links
http://www.medical-hypotheses.com/article/S0306-9877(01)91352-0/abstract
Citation
Classen, J.b., and D.c. Classen. "Vaccines and the Risk of Insulin-dependent Diabetes (IDDM): Potential Mechanism of Action." Medical Hypotheses 57.5 (2001): 532-38.
“Immunization with a number of different vaccines, including live and killed vaccines, has been linked to the development of insulin-dependent (type 1) diabetes in humans and animals. Multiple different mechanisms have been proposed to explain the association between vaccines and diabetes. The current paper reviews multiple different mechanisms by which vaccines are known to manipulate the immune system and can induce an autoimmune disease such as type 1 diabetes. Genetic variability may determine which of these pathways, or possible other pathways, predominate in an individual following immunization.”
Links
http://www.medical-hypotheses.com/article/S0306-9877(01)91352-0/abstract
Citation
Classen, J.b., and D.c. Classen. "Vaccines and the Risk of Insulin-dependent Diabetes (IDDM): Potential Mechanism of Action." Medical Hypotheses 57.5 (2001): 532-38.