Aluminum Exposure Linked to Infertility in Men

aluminum cansThe study “Aluminum content of human semen: Implications for semen quality,” (you can read it here… )  found the mean semen aluminum content to be very high at 339 micrograms /L and a direct association with lower sperm count the higher the semen aluminum content went.  We know there has been a significant decline in fertility and sperm counts over the past few decades with previous research suggesting this was due to endocrine disruptors (plastics like BPA, pesticides and herbicides, fire retardants).  This study is important as it showed extremely high aluminum content of the semen, exceeding 500 ppb in some.  The higher the aluminum, the lower the sperm count.

Aluminum is discussed in our governments Statement on Aluminum and public health found here… The listed major sources as being around mining and processing of aluminum ores and from coal fired energy plants.  They do not include the aluminum in vaccines which for children is a huge source of aluminum exposure.  I refer you to a previous blog (here… ) on this topic and include all the references at the bottom of this blog.  It is clear that human exposure to aluminum has been increasing over the pat decades and this trend is potentially very detrimental to not only our health but the ultimate survival of the human race.

ADDITIONAL REFERENCES

[1] J. A. T. Pennington and J. W. Jones, Aluminum and Health: A Critical Review, ed H. J. Gitelman (Marcel Dekker, NY, 1989).

P.F. Zatta and A.C Alfrey, Aluminium Toxicity in Infants’ Health and Disease (World Scientific Publishing Co. 1997)

Research Issues in Aluminum Toxicity ed R. A Yokel and M. S. Golub (Taylor and Francis 1996, 1997)

[2] Koo WWK, Kaplan LA, Bendon R, et. al. Response to aluminum in parenteral nutrition during infancy. J. Pediatr 1986;109:877-883.

Koo WWK, Kaplan LA. Et. al. Response of preterm infants to aluminum in parenteral nutrition. JPEN J Parenter Enteral Nutr. 1989; 13: 516-519

[3] Bishop NJ, Morley R, Day JP, Lucas A aluminum neurotoxicity in preterm infants receiving intravenous-feeding solutions. N. Eng. J Med 1997;336:1557-1561.

[4] Nathan, E and Pedersen, S 1980 Dialysis encephalopathy in non-dialysed uremic boytteated with aluminum hydroxide orally. Acta Paediatr. Scand. 69:793-796.

Andresoli, S P., Bergstein, J M. and Sherrard, D. J. 1984. Aluminum intoxication from aluminum-containing phosphate binders in children with azotemia not undergoing idalysis. N. Engl. J. Med. 310:1079-1084.

[5] Food and Drug Administration. Aluminum in large and small volume parenterals used in total parenteral nutrition; amendment; delay in effective date. Fed Regist. 2002;67:70691-70692.

[6] ASCN/ASPEN working group on Standards for Aluminum Content of Parenteral Nutrition Solutions, Parenteral drug products containing aluminum as an ingredient or a contaminant. Am. J. Clin. Nutri. 1991. 53:309-402

[7] Klein, G. Aluminum Congtent of Parenteral Nutrition Products in book Zatta, P.F. and Alfrey, A. C. Aluminum Toxicity in Infants’ Health and Disease. 1997 157-167.

[8] Fanni, D. et. al. 2014. Aluminum exposure and toxicity in neonates: a practical guide to halt aluminum overload in the prenatal and perinatal periods. World J Pediatr. May: 10(2):101-7

[9] Tomljenovic, L. and Shaw, C.A. 2012 Lupus 21(2):223-230.

[10] Andress, D. L. , Kopp, J. B. et. al. Early deposition of aluminum in bone in diabetic patients on hemodialysis. N. Engl. J. Med. 316:292-296

Bishop N. J. et. al. 1989. Increased concentration of aluminum in the brain of a parenterally fed preterm infant. Arch. Dis. Child. 64:1316-1317

[11] Priest. N. D. et. al. Hum. Exp. Toxicol. 1995 (14):287.

[12] Eagle, W. D. 1986 Evaluation of renal function and acute renal failure in the neonate. Pediatrt Clinic N, America 33:129-151.

[13] Moreno, A Domingues, C. and Ballabriga, A. 1994 Aluminum in the neonate related to parenteral nutrition. Acta. Paediatr. 83:25-29.

[14] Birchall, J. D. and Chappell, J. S. Aluminum, chemical physiology and Alzheimer’s disease. Lancet 2 (1988) 1008.

[15] Karlik, S. J. et. al. 1980, Interaction of aluminum species with DNA. Biochemistry 19, 5991.

Troncoso, J. C. et. al. 1986. Immunocytochemical studies on neurofilament antigens in the neurofibrillary pathology induced by aluminum. Brain Res. 364:295

[16] Trapp, G. A. 1980. Studies of Aluminum interactions with enzymes and proteins. Neurotoxicology 1:89

[17] Dominguez, M. C. et. al. 1994. Effect of aluminum and lead salts on lipid peroxidation and cell survival in human skin fibroblasts. Biol. Trace Elem Res. 57.

[18] Tariq, M. 1993 A review of reproductive toxicity of aluminum. In Reproductive toxicology, Ed M. Richardson, pp 245-261.

[19] Cherroret, G et. al. 1992. Long-term effects of postnatal aluminum exposure on choline acetyl transferase activity and learning abilities in the rat. Neurotoxicol. Teratol. 14:259-264

Golub, M. S. et. al. 1987 Maternal and developmental toxicity of chronic aluminum exposure in mice. Fund. Appl. Toxicol. 8:346-357

Golub, M. S. et. al. 1995 Behavioral performance of Swiss Webster mice exposed to excess dietary aluminum during development or during development and as adults. Toxicol. Appl. Pharmacol. 133:64-72

Muller, G. et. al. 1990. Developmental alterations in offspring of female rats orally intoxicated by aluminum lactate at different gestation periods. Teratology 42:253-261.

Reuhl, K. R. 1991. Delayed expression of neurotoxicity: The problem of silent damage. Neurotoxicity 12:341-346.

Santucci, D et. al. 1994. Early exposure to aluminum affects eight-arm maze performance and hippocampal nerve growth factor in adult mice.

Yorkel, R. A. 1985 Toxicity of gestational aluminum exposure to the maternal rabbit offspring. Toxicol. Appl. Pharmacol. 79:121-133.

[20] National Health Statistics Reports Number 65, March 2013. Changes in Prevalence of Parent-reported Autism Spectrum Disorder in school age children 2007 – 2012.

[21] Suren, P. et. al. 2013 Association between maternal use of folic acid supplements and risk of autism spectrum disorders in children. 309(6):570-7

[22] Gallagher, C. M. and Goodman, M. S. 2010 Hepatitis B vaccination of male neonates and autism diagnosis, NHIS 1997-2002. J. Toxicol. Environ. Health A 73(24):1665-77

[23] Tomljenovic, L. and Shaw, C.A. Do aluminum vaccine adjuvants contribute to the rising prevalence of autism? J. Inorg. Biochem. 2011 105(11):1489-99.

[24] Shaw, C.A. and Petrik, M.S. 2009. Aluminum hydroxide injections lead to motor deficits and motor neuron degeneration. 103(11): 1555-62/

[25] Exley, C. et. al. 2009. A role for the body burden of aluminum in vaccine-associated macrophagic myofasciitis and chronic fatigue. Med. Hypoptheses. 72(2):135-9

[26] Seneff, S., Davidson, R.M. and Liu, J. 2012 Empirical Data Confirm Autism Symptoms Related to Aluminum and Acetaminophen Exposure. Entropy 2012, 14, 2227-2253.

[27] Pittman, M. and Cox, C. B. 1965. Pertussis Vaccine Testing for Freedom-from-toxicity. Appl. Microbiol. 13(3):447-456.

[28] Wu, T. W., Lin, H.H., Wang, L.Y. 2013. Chronic hepatitis B infection in adolescents who received primary infantile vaccination. Hepatology 57:37-45

Keck, J.W. et. al. 2014 Hepatitis B Antibody Levels seven to nine years following Booster Vaccination in Alaska Native persons. Clin. Vaccine Immunol. July 23 pii: CVI.00263-14.

Dr. Paul

 

Reply To This Post