Inflammation Related to Being Overweight Linked to Type-2 Diabetes
We know that type-1 diabetes is caused by an immune attack on the pancreas that eventually destroys the pancreatic islets ability to make insulin, making a diabetic insulin-dependent for life. This immune attack is thought to be auto-immune, meaning that you are making antibodies against your own body (in this case the islet cells of the pancreas). The study “Accumulation of M1-like macrophages in type-2 diabetic islets is followed by a systemic shift in macrophage population” illustrated that type-2 diabetes (T2D) is not only characterized by low grade systemic inflammation and loss of beta-cells and insulin production in the pancreas but they demonstrate increased macrophages invading the pancreas in the early phase of T2D. They specifically showed that there was a 4-fold increase in macrophages and an 8-fold increase in the CD68+F4/80- macrophages with increased cytokine levels causing initial inflammation then fibrosis of the pancreas islet cells.
Since 25% of US adults over 65 have T2D and over 50% of the population is pre-diabetic; (Data Here), the important take home message here is to do everything you can to keep weight optimal and inflammation minimal. How, you may ask?
1. Avoid sugars, artificial sweeteners, and processed foods.
2. Avoid wheat, and for many, gluten and other highly refined sugars.
3. Numbers 1 & 2 above result in increased insulin which triggers fat storage and inflammation.
4. Take your purified fish oil or organic flax, and other nutritious sources of omega-3.
5. Take vitamin D (up to 5000 IU a day for adults, and 1000 IU a day from birth).
6. Drink enough purified water (up to a gallon a day for adults).
8. Minimize stress in your life (have healthy relationships, avoid toxic people and places, get some down time for yourself).
9. Get enough sleep- a minimum of 7-8 hours/night (more for children and teens).