Endocrine Disruptors and Their Connections With Austism and ADHD

Have you seen our newest YouTube video on kids getting shots? It will make you laugh! See it Here
There is evidence that endocrine disruptors (think environmental toxins like BPA/plastics, PCB’s, dioxin, and more) are causing or contributing to autism/ ASD/ ADHD.  There is an emerging understanding in the endocrinology community of Toxicant Induced Loss of Tolerance (TILT)  and I am increasingly convinced there may be a similar TILT phenomenon with the thyroid.  Our children may have “normal” thyroid levels but the circulating thyroid hormones are not effective at the receptors (the cell level).  This would be as if they were hypothyroid, and is called functional hypothyroidism.  This state of functional hypothyroidism would lead to low cellular energy, and specifically can lower GABA, a major calming neurotransmitter.  With low GABA, our children can have seizures at extreme deficiency and anxiety and panic attacks at moderate levels of deficiency. 

Here is an interesting article demonstrating just how much we already know on this topic of endocrine disruptors and Autism Spectrum/ ADHD-

Does perinatal exposure to endocrine disruptors induce autism spectrum and attention deficit hyperactivity disorders?
Acta Paediatr. 2012 Aug;101(8):811-8. doi: 10.1111/j.1651-2227.2012.02693.x. Epub 2012 May 7.

de Cock MMaas YGvan de Bor M.


Department of Health and Life Sciences, VU University, Amsterdam, The Netherlands.



To provide an overview of studies on perinatal exposure in humans to endocrine disrupting chemicals (EDCs) in relation to autism spectrum (ASD) and attention deficit hyperactivity (ADHD) disorders.


A review of the literature (PubMed) was performed. Exposure-related keywords, including various chemicals, were matched with keywords describing outcome. Animal studies as well as publications not written in English were excluded. In total, 834 titles were retrieved. The final selection included 21 publications.


Positive associations were found for ASD in relation to exposure to all chemicals investigated, which included hazardous air pollutants, pesticides and bisphenol A (BPA). Increased risks of ADHD or positive associations were found for exposure to polychlorinated biphenyls (PCBs), dialkyl phosphate (DAP) and chlorpyrifos. BPA, polybrominated diphenylethers (PBDEs) and low molecular weight (LMW) phthalates were positively associated with externalizing behaviour. Five of 17 studies did not find any association between exposure and ADHD.


Perinatal exposure to EDCs appears to be associated with the occurrence of ASD as well as ADHD. Disruption of thyroid hormone function and gamma-aminobutyric acid (GABA)ergic mechanisms may offer an explanation for the observed relations; though, conclusive evidence in humans is limited.

© 2012 The Author(s)/Acta Paediatrica © 2012 Foundation Acta Paediatrica.

Dr. Paul

Mercury Intake During Pregnancy Increases Risks of ADD/ADHD

Increased mercury in mom during pregnancy (which is known to be associated with increased fish consumption in pregnancy) – is directly linked to severity and likelihood of having your baby/ child develop ADD or  ADHD.

Think toxins, toxins,  toxins!  As toxin burdens rise in our bodies – it becomes ever more important to do everything we can to reduce toxic exposures of all toxins in our children.  

Here is the Article Abstract For You to Read:

Prenatal Exposure to Mercury and Fish Consumption During Pregnancy and Attention-Deficit/Hyperactivity Disorder–Related Behavior in Children Sharon K. Sagiv, PhD, MPH; Sally W. Thurston, PhD; David C. Bellinger, PhD, MS; Chitra Amarasiriwardena, PhD; Susan A. Korrick, MD, MPH
Arch Pediatr Adolesc Med. 2012;():1-9. doi:10.1001/archpediatrics.2012.1286.
Published online October 2012

Objective  To investigate the association of prenatal mercury exposure and fish intake with attention-deficit/hyperactivity disorder (ADHD)–related behavior.
Methods  For a population-based prospective birth cohort recruited in New Bedford, Massachusetts (1993-1998), we analyzed data for children examined at age 8 years with peripartum maternal hair mercury measures (n = 421) or maternal report of fish consumption during pregnancy (n = 515). Inattentive and impulsive/hyperactive behaviors were assessed using a teacher rating scale and neuropsychological testing.
Results  The median maternal hair mercury level was 0.45 μg/g (range, 0.03-5.14 μg/g), and 52% of mothers consumed more than 2 fish servings weekly. In multivariable regression models, mercury exposure was associated with inattention and impulsivity/hyperactivity; some outcomes had an apparent threshold with associations at 1 μg/g or greater of mercury. For example, at 1 μg/g or greater, the adjusted risk ratios for mild/markedly atypical inattentive and impulsive/hyperactive behaviors were 1.4 (95% CI, 1.0-1.8) and 1.7 (95% CI, 1.2-2.4), respectively, for an interquartile range (0.5 μg/g) mercury increase; there was no confounding by fish consumption. For neuropsychological assessments, mercury and behavior associations were detected primarily for boys. There was a protective association for fish consumption (>2 servings per week) with ADHD-related behaviors, particularly impulsive/hyperactive behaviors (relative risk = 0.4; 95% CI, 0.2-0.6).
Conclusions  Low-level prenatal mercury exposure is associated with a greater risk of ADHD-related behaviors, and fish consumption during pregnancy is protective of these behaviors. These findings underscore the difficulties of balancing the benefits of fish intake with the detriments of low-level mercury exposure in developing dietary recommendations in pregnancy.

Dr. Paul

Pesticides May Be Linked to ADHD

Exposure to Pesticides May Increase
Occurrence of ADHD

New research reported in the June issue of Pediatrics, suggests that exposure to high levels of organophosphate pesticides may increase the odds for attention-deficit/hyperactivity disorder (ADHD) in children.

Going organic, buying at farmers’ markets and washing fruits and vegetables thoroughly before consuming them, is the best way to minimize pesticide exposure.

“Organophosphates are one of the most widely used pesticides in agriculture.”

In their study, Bouchard and her colleagues analyzed data on pesticide exposure and ADHD in more than 1,100 American children aged 8 to 15.

“The higher the level of exposure [as measured by metabolites in the urine], the higher the odds of having ADHD,” Bouchard added.

High doses of organophosphates may inhibit acetylcholinesterase, a nervous system enzyme, and may affect different growth factors and neurotransmitters.

These findings may provide another clue into the causes of ADHD, a condition which affects one in fourteen school-aged children, according to the U.S. Centers for Disease Control and Prevention. Autism and other chronic disorders of brain and development may also be affected by pesticides, though this was not mentioned in this article.

At least one-third of fathers who have had ADHD in their youth have a child with ADHD.” Perhaps the inability to excrete (detox) pesticides is the possible reason.

The time is now to get serious about eating organic from the day of conception throughout our lives.

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