Stress and Anxiety During Pregnancy Linked to Autism, ADHD, and Anxiety in Children – Hypomethylation Related

200447888-001Anything we can do to reduce the chances our children will suffer from autism, ADD, ADHD, anxiety, etc. would be worth paying attention to right?

I have published a blog (you can see it here… ) showing that maternal folate supplements cut that risk in half.  You will hear over and over that most health issues are “genetic” but they are referring to epigenetic, meaning how our genes respond to the environment (we can often make the environment friendly rather than hostile). 

The study (you can read here… ), “Differential gene body methylation and reduced expression of cell adhesion and neurotransmitter receptor genes in adverse maternal environment”, is an important study, complicated beyond words in the details. I see two very important take home messages:

1.  Avoid maternal stress during pregnancy, it can harm your unborn child when mom is stressed. Treat her like a queen!

2.  Support methylation, and I would recommend in addition to methyl-folate, methyl-B12 and a B-complex.  (Ceralin Forte by Metagenics does it all in one supplement and is available at my office or from Metagenics). Get advice from your provider on whether or not this might be OK for your specific case, but if it were my wife or child I would have them take just one capsule a day (not the 3 recommended on the bottle), along with her prenatal vitamin, extra vitamin D for a total of 4-5,000 IU vitamin D3 a day, omega-3, and make sure the prenatal vitamin has iodine. 

Single nucleotide polymorphisms (SNP’s) are unique codes in our genetic code that respond to the environment.  In this study CRHR1, DRD3, ADORA2A, CHRNA4, GABRG3, and GABBR2 were all methylated differently in the stressed moms and are linked to anxiety. Differential methylation was also detected in GRIN1, the gene for the NMDA NR1 subunit and in GRIK3 and GRIK4 the genes for KA receptor subunits.  Other SNP’s with differential methylation leading to anxiety were the GRIP1, SHANK1, 2, 3 as well as the CACNA1C and KCNJ genes. 

What is exciting, is that with almost all these SNP’s where we each may have hundreds if not thousands of “glitches” (most unknown at this point) representing genetic strengths and weaknesses in enzyme systems and neurotransmitters, rather than thinking you are doomed, you can do something about it.  In most cases, health is just a few supplements, and healthy living life-style changes, away!  Support methylation by taking methyl-B12, methyl-folate, and consider getting your genetic profile tested.  Consider having Spectracell drawn so you will know specifically which nutrients are not getting into your cells.  Spectracell is offered at Integrative Pediatrics for children ( , and at Natura Integrative Medicine ( for adults.



Dr. Paul



AAP Pushes the Tdap for All Pregnancies (NOT A GOOD IDEA)

pregnant-heartAAP (Academy of Pediatrics) News release Feb 1, 2014:  Dr Sarah Long MF FAAP, member of the AAP committee on infectious diseases, (read here…. ) outlines the position of the AAP.  She points out that “recommendations for Dtap use have not changed in more than a decade and include routine administration of the infant series at 2, 4 and 6 months of age, and reinforcing doses at 12 to 18 months and 4 to 6 years.” 

This article is stressing the new changes effective in 2014; “The most recent change, which was included in the 2014 Immunization Schedule, is the recommendation for Tdap administration during each pregnancy, preferably between 27 and 36 weeks of gestation and regardless of time since last Tdap or Td.”

What concerns me and should concern anyone who is thinking clearly about this recommendation is that there have been no studies on the effects of injecting this vaccine during pregnancy. NO STUDIES!   This article mentions: “Why are repeated doses of Tdap not recommended routinely for the general population other than pregnant women? Data do not support a substantial impact of a broader recommendation on pertussis control, and lack of data and licensure are cause for pause.” 

It seems our experts who make vaccine recommendations care about lack of data and licensure when it comes to recommending routine boosters for the general population, but can recommend injecting pregnant women with this vaccine and it’s 330 micrograms of aluminum without any studies or data on the safety of such a recommendation.  Any researcher who wanted to study this would need an IRB (Institutional Review Board) approval to inject half the pregnant women with the Tdap and half with saline then look for 5-10 years at the outcomes (how many cases of brain injury from the toxic aluminum: autism, ADD, ADHD, anxiety, depression, learning challenges etc.).  I cannot find a single study like this in humans or even primates. 

There are plenty of studies raising concerns about aluminum toxicity.  One recent study (you can read it here… ) showed vaccine concentrations of aluminum after birth, triggering autism like symptoms. There is no doubt that injecting aluminum during pregnancy will result in a much higher risk to the developing fetal brain. 


JUST SAY NO to Tdap during pregnancy!

This issue is about balancing risks and benefits.  Does the risk of poisoning an entire generation (every baby born in America whose mother gets the Tdap)  justify the handful of potential saved lives (those rare infant deaths in the first few months of life before the usual vaccine schedule has time to work)?  I think as physicians we should “First Do No Harm”.  This vaccine recommendation clearly causes harm, we just have to wait 5-10 years to see the explosion of the Autism, ADD, ADHD, anxiety, depression, learning disorders, etc.  Make sure your physician is giving you informed consent (telling you about the aluminum in the vaccine, the absence of safety studies on pregnant women, and the known aluminum toxicity), before you agree to take this vaccine while pregnant.


Dr. Paul




“Dear Parents, You Are Being Deceived About Vaccines and Autism”

liarDr Paul is not against all vaccines.  He does, however, encourage parents to make informed decisions about which vaccines to do and when to do them. 

This blog article points out several very important truths:

1.  Conflicts of interest do exist.  Paul Offit MD, co-patent holder on rotateq, sat on the ACIP committee that made the recommendations for that vaccine to be given here and now worldwide making millions. That vaccine has killed children and has caused intussusceptions. Virtually no one is dying from rotavirus infection in this country.

2.  The media would have you believe we are in a measles epidemic, and you should rush in to get your measles vaccine.  In fact, during the past decade, we have had less than 1000 cases a year in the entire country of over 300 million people.  That puts the risk at about 1 in every 500,000. Ohio had 42 cases out of 11.5 million people (risk= 1 in 274,000).  California had 59 cases out of 38 million people (risk= 1 in 644,000) and NY had 26 cases (risk= 1 in 754,000).  These risks are comparable to that of being struck by lightning which has killed 20-40 Americans each year.  The last death from measles in the US was in 2005!

3.  Vaccines do cause autism. Read the blog linked to at the bottom of this post. I have a practice with around 200 severe autistic children. Over half of the families have no doubt that it was caused by the MMR, or sometimes a set of vaccines given all at once, often at 12, 15, or 18 months of age. 

4.  The Hepatitis B vaccine, when given to neonates as most do in this country has been shown to increase autism as can be seen on this link…


5.  The study has not been done comparing autism rates or ADD and ADHD and anxiety rates etc. in non-vaccinated compared to vaccinated or partially vaccinated children.  WHY?  Might it be fear by physicians of loosing their license to practice medicine?  Remember Andrew Wakefield?  He was ultimately stripped of his license for publishing an article that showed a possible link between the MMR and autism. I  know he was right, but no one would dare risk following his foot steps!  He did not falsify data as they alleged, and that has been proven in court. His findings have been reproduced.  So until the big studies are done that will show vaccines are more dangerous as currently recommended by the AAP than doing nothing or doing a modified schedule, as I promote, parents need to educate themselves.


This blog is a must read and click on the links. Please read it here…



Dr. Paul

CDC Releases Report: Autism Now Affects 1 in 68 as of 2010! What Can You Do?

autismrainbowToday, April 2nd, 2014, is autism awareness day.  April is Autism awareness month.  Just in time for that, the CDC has released data showing that 1 in 68 US children today have autism in some form when looking at 8 year olds. You can read their report here…  Regardless of the actual statistic, anyone with their eyes open and a shred of common sense knows that something terrible is going on here with our children’s brains.  Ask the grandparents alive today how many autism cases they remember when they were kids? ZERO.  Ask older pediatricians (nearing 60 or older) how many cases they remember back in the early 1980’s or before? Almost none!  

If your child may have autism or does have autism, or some other form of less than “normal” brain function, my heart goes out to you.  It is my passion to educate the world on what is going on and pointing families towards ways to help those suffering. Also, and very importantly, how to avoid this happening to you again with subsequent children. Children with autism almost always are highly intelligent, but that intelligence is not always accessible to them. Almost all children with autism get better to some degree.  There are things you can do to promote that process and speed up the recovery. Search autism on my blogs for some more information. So what can a parent or future parent do?

The list of potential causes of autism is a good start.  Clearly with toxins 1+ 1 + 1 may = 10 and we know babies are now exposed to numerous known neurotoxins in the womb, the first big hit.  Why on earth would we want to inject 170-330 micrograms of aluminum into pregnant moms, as is now being done starting in 2012 with the Tdap!? 

I have 10,000 active patients, 167 diagnosed with autism in the chart (more who wouldn’t let me use that label), 570 ADD or ADHD and a much lower rate than the 1 in 50, 1 in 67, or 1 in 100 that the literature is quoting. The rate in my office is much lower in patients who started with me.  Most of my autism cases joined my practice due to the unique approaches that help most of them get better.  Not all fully recover. 

 Out of the 1000 kids in my practice that are 3 years old, I have one with autism, and that one had a sibling with autism.   So what is the reason for the reduced numbers?

I suspect it is due to the following interventions in my practice:

1.      I counsel prenatal visits not to get the Tdap while pregnant.  That recommendation isn’t in my stats as it is new, but when the rate of ASD reaches 1 in 20 over the next 10-20 years, I suspect the Tdap while pregnant will be a big contributor. Other countries won’t see that as they are not giving the Tdap in pregnancy, yet.

2.      Don’t give the Hep B vaccine with it’s 250 micrograms of aluminum to newborns, 2 months olds, or 6 month old babies if mom is Hep B negative.

3.      Put pregnant moms on 5000 IU vitamin D and newborns on 1000 IU per day, starting at birth. 

4.      Encourage eating organic, GMO-free food and drinking filtered water.

5.      Don’t give the MMR until age 3 unless there is a local epidemic or travel to a high risk area.

6.      If at high risk for autism (sibling, parent, lots of auto-immune issues) don’t vaccinate or do so VERY  VERY slowly.

7.      At the first sign of any neurological issue, even reduced eye contact, stop vaccines, identify and avoid food sensitivities, determine nutrient deficiencies and replace them, review possible toxin exposures, and offer services. 

Now these are recommendations of what I would do if it were my wife or my child.  I do educate about the standard vaccine schedule and that the standard schedule is the “recommended schedule”.

Somehow we need someone with access to data to pull it out for us and compare fully vaccinated, partially-vaccinated and unvaccinated kids with similar risk factors, looking at rates of neurological challenges (ASD, ADD, ADHD, depression, anxiety, etc.).  With genetic information finally really becoming affordable and accessible, we should also be able to find out which SNP’s put you at greater risk and perhaps we can avoid triggering ASD, etc., by slowing down the vaccine schedule further for those at highest risk, e.g.  those with MTHFR.  There are also ways to support the biochemistry of those with particular risks.  
EXAMPLE: If you have MTHFR defect, supplementing B2, B3, B6, methyl-folate, methyl-B12, NAC will optimize methylation and minimize risks. 

Pesticides, herbicides, plastics, and other endocrine disrupters are all huge parts of this puzzle. Europe seems way ahead of us in protecting the environment and the population.  Sadly, will we need to have 90% of boys and 50% of girls poisoned before we pay attention to this?  At the rate we are going, that may only take a decade or two.  We won’t have generations to figure this out – this will bankrupt the USA and destroy our brain power. 

We have the science.  Where is the integrity in our leaders and the scientific community? 



Dr. Paul

1 2 3 4 5 8