GABA Receptor Polymorphism Associated with Autism Spectrum Disorder (ASD)
GABA is the main calming neurotransmitter in the brain. Those with autism, ASD, and indeed ADHD and anxiety might be expected to have issues with the GABA receptor. The study, “Association between GABA(A) receptor subunit polymorphisms and autism spectrum disorder (ASD)”, found:
- Significant differences in allele freq. (ASD patients versus controls): rs1912960 GABRA4.
- Significant differences in genotype freq. (ASD patients versus controls): rs1912960 GABRA4.
- Haplotypes: markers rs1912960 (GABRA4) and rs211037 (GABRG2) overrepresented in ASD.
- GABRA4 involved in etiology of ASD in Argentinean sample independently or with GABRG2.
You can read this study for yourself by clicking here…
As the hundreds of thousands or millions of polymorphisms are identified and associations are found, we will gradually learn more and more about what makes each of us more vulnerable to various disorders and diseases. These same polymorphisms may offer strengths that allow us to survive better under various stresses. The key to ongoing health and wellness will be determining which environmental stresses are most dangerous for which individuals. Someone who cannot handle a particular stress might be guided to avoid certain careers which have high exposures to which they genetically are vulnerable.
Some polymorphisms might make you more vulnerable to vaccine damage. We know that those with autism (ASD) are more likely to have the SNP MTHFR. The study, “Association of MTHFR Gene Variants with Autism,” showed, “increased frequency of the homozygous mutation 677CT allele (TT): 23% in the autistic children compared to 11% in the control population (P<0.0001).” You can read that study here… When you have this defect, you cannot methylate folate to the vital methyl-folate making your ability to methylate (turn on and off genes) and your ability to get rid of toxins, impaired. These are children who would not do well with toxin containing vaccines for example. If the researchers would look at these aspects, we could selectively shield those vulnerable to vaccine damage from getting certain vaccines, for example. We are still in the early stages of identifying polymorphisms. Determining their meaning and what we choose to study will determine whether or not this huge data base will lead to better health or just more drugs.