Acetaminophen (paracetamol)- Dangerous for Pregnancy and Young Children

AcetaminophenMy pregnant moms all tell me that their doctors and nurses encourage the use of acetaminophen (Tylenol) during labor and right after the baby is born for pain control. I know pediatricians recommend acetaminophen over ibuprofen, as the pain reliever for those under 6 months since ibuprofen has not been approved for use in that age group. What if this medication was actually highly toxic, and shut down your major detoxification molecule glutathione? It turns out that acetaminophen is extremely toxic, and a potent inhibitor of glutathione. Imagine, most newborns in America being given a huge dose of toxic aluminum (250 micrograms) with the Hepatitis B vaccine right at birth, then acetaminophen for pain, either because of a circumcision, or for some other reason. Newborns have reduced excretion of the aluminum, which is partially stored in the brain. Read more here…

In the article, “Evidence that Increased Acetaminophen use in Genetically Vulnerable Children Appears to be a Major Cause of the Epidemics of Autism, Attention Deficit with Hyperactivity, and Asthma,” Dr Shaw points out that, “toxicity of acetaminophen may cause autism by overloading the defective sulfation pathway catalyzed by phenolsulfotransferase, which is deficient in autism, leading to overproduction of the toxic metabolite N-acetyl- p-benzoquinone imine (NAPQI). Increased levels of NAPQI reduce the ability to detoxify a host of toxic chemicals in the environment, increasing oxidative stress, which leads to protein, lipid, and nucleic acid damage from free radicals.” The article diagrams beautifully the metabolic pathways and alterations that occur with acetaminophen. I agree with his call of, “large-scale trial of acetaminophen restriction in pregnancy and the first 3 years of life is warranted to test the hypothesis that acetaminophen is a causative agent in autism, asthma, and attention deficit with hyperactivity.” You can read this article here… 

In the study, “Acetaminophen (paracetamol) use, measles-mumps-rubella vaccination, and autistic disorder,” a survey of parents of autistic and age-matched controls showed a significant correlation for autism if acetaminophen was given with the MMR. You can read more on this here…  This correlation did not exist if ibuprofen was used for fever control around the time of the MMR. The correlation was strongest for those who regressed and especially strong when considering just those children with post-vaccination sequelae. While this study was just a small phone survey study, this possible association certainly warrants further investigation.

 

 

 

 

Dr. Paul

 

 

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