Antidepressants and Pregnancy- Which to Avoid?

pregnant-heart     If you are a woman of child-bearing age, who could get pregnant, this study is vital. Do not take fluoxetine (Prozac), or paroxetine (Paxil). I have found, when doing genetic studies for potential metabolic problems with the metabolism of SSRI’s (Selective Serotonin Reuptake Inhibitors) that many of us have problems metabolizing all but the escitalopram. This combined with this study, would make escitalopram (Lexapro) the best chioce if you must use an SSRI for depression or anxiety.

In the study, “Specific SSRIs and birth defects: bayesian analysis to interpret new data in the context of previous reports,” CDC researchers analyzed about 20,000 mothers of infants with birth defects and 10,000 mothers of infants without birth defects, between 1997 and 2009. They looked at citalopram, escitalopram, fluoxetine, paroxetine, or sertraline use in the month before through the third month of pregnancy and then the odds of birth defects.

They found no increased risk of birth defects with the antidepressants sertraline (Zoloft), citalopram (Celexa) and escitalopram (Lexapro). The analysis did find an association between birth defects and the antidepressants fluoxetine (Prozac) or paroxetine (Paxil); heart defects, abdominal wall defects, and missing brain and skull defects with paroxetine, and heart wall defects and irregular skull shape with fluoxetine. The relative risk increased 2 to 3.5 times, depending on the defect and the medication.

You can read this study here…

Dr. Paul




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