Increased Homocysteine Correlates With Language Issues in Autistic Children

Methylation-cycleThe article, “Increased homocysteine levels correlate with the communication deficit in children with autism spectrum disorder,” found that the amount of homocysteine autistic children excreted increased in proportion to their language deficit. They “highlight”:

  • No biomarker of core symptoms of ASD have been described.
  • Homocysteine concentration is increased in children with ASD.
  • The increase correlates significantly with the severity of the communication deficit.
  • Homocysteine could be a potential diagnostic tool useful to evaluate new treatment options in ASD. You can read the article here…


This comes as no surprise to me as we know that those with the MTHFR genetic defect (especially if homozygous for C699T) have severely reduced ability to take homocysteine to methionine in the methylation cycle. I believe this issue is very important, as the inability to convert homocysteine to methionine reduces your ability to methylate (a key reaction in virtually all of our biochemistry) and reduces our ability to get rid of toxins from the body making us much more vulnerable to the increased toxins in food, water, air, and vaccines.

The authors mention, “no treatment for core symptoms of ASD are available,” and I would have to disagree, as knowing your homocysteine is elevated (either in blood or in urine as they found in this study) can prompt you to take methyl folate (and avoid regular folate) and methyl B-12. You can also take trimethylglycine/TMG (betaine) and activate a shortcut from homocysteine to methionine.


Dr. Paul



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