Toxic Metals (Lead, Antimony, Mercury, Aluminum), Reduced Glutathione and Autism

HeavyMetals2     In the study, “The Severity of Autism Is Associated with Toxic Metal Body Burden and Red Blood Cell Glutathione Levels,” researchers “found that the body burden of toxic metals (as assessed by urinary excretion before and after DMSA) was significantly related to the variations in the severity of autism, for each of the four scales. The metals of greatest influence were lead (Pb), antimony (Sb), mercury (Hg), tin (Sn), and aluminum (Al).” This study found significant correlations of severity of autism and the urinary excretion of toxic metals, such that a higher body burden of toxic metals was associated with more severe autistic symptoms. Lower initial levels of glutathione, a key detox molecule in the body, were associated with greater severity of autism.

From other studies we know organophosphates, PCB’s, BPA, and PBDE’s (watch a video  here… )  and the Environmental Health Perspectives review (which can be found here… )  listed the main neurotoxins as:


Lead (Jusko et al. 2008)

Methylmercury (Oken et al. 2008)

Polychlorinated biphenyls (Winneke 2011)

Organophosphate pesticides (Eskenazi et al. 2007; London et al. 2012)

Organochlorine pesticides (Eskenazi et al. 2008)

Endocrine disruptors (Braun et al. 2011; Miodovnik et al. 2011)

Automotive exhaust (Volk et al. 2011)

Polycyclic aromatic hydrocarbons (Perera et al. 2009)

Brominated flame retardants (Herbstman et al. 2010)

Perfluorinated compounds (Stein and Savitz 2011).


There is undoubtedly a role acetaminophen plays in altering glutathione and thus magnifying the toxicity of heavy metals and other toxins, since most toxins need adequate glutathione for elimination from the body.

You can read my blog about acetaminophen here…


Dr. Paul




Testosterone Therapy Not Associated with Increased Blood Clots (study)

heart4It is an interesting time in the world of hormone therapy these days. Here in Oregon, a teenager or woman can legally buy synthetic hormone birth control pills (BCP’s), with known complications of thromboembolism (blood clots) that can be fatal, while hypogonadism, low testosterone men with multiple symptoms of low testosterone can’t even find a doctor willing to prescribe the bio-identical (much safer) testosterone to replace his deficiency! To make this insanity worse, Oregon now allows purchase of BCP’s from a pharmacist without a prescription (law passed though not implemented yet).

I’ve seen law firm commercials seeking to represent men who have had a stroke or blood clot so they can sue the doctors and pharmaceutical companies when in fact the bulk of the literature is clear that hormone replacement therapy for men who are low testosterone improves all major health outcomes: lowering heart disease, stroke, diabetes risk and reducing weight, builds muscle, and improves depression, anxiety, and libido to name a few benefits.

The June 2015 article, “Risk of Venous Thromboembolism (VTE) in Men Receiving Testosterone Therapy,” did a case control study of over 30,000 men over the age of 40 who had VTE and received anticoagulant drugs in the 60 days after their diagnosis of VTE. They looked at those with testosterone replacement therapy in the 15 days before the VTE event and compared them to matched controls. They found no increased risk of VTE for those on testosterone replacement therapy and in fact, for those using topical forms of testosterone, there were modest reductions in risk with adjusted odds ratio with 95% confidence of 0.80 for topical testosterone, 0.91 for transdermal, and 1.15 for intramuscular.

I continue to favor the use of topical, or transderma,l over intramuscular as you can provide a more normal daily dose, rather than the huge spikes of testosterone needed when giving weekly or bi-weekly injections.

Why this physician resistance to assist men who are both physiologically and lab confirmed low testosterone, and who have symptoms of low testosterone is beyond comprehension. I suspect it is due to the past and some ongoing abuse of testosterone by body builders and not wanting to be associated with that. Physicians need to know that their low testosterone patients will not be able to abuse the testosterone when prescribed in normal doses. Body builders abusing steroids are using insanely large doses often 5 to 10 times the usual dose.

Men and for that mater teenagers who are done with puberty, should get their testosterone levels checked, especially if suffering from anxiety, depression, fatigue, weakness, low energy, weight gain, poor muscle development, or low libido (sex drive). Our world is so full of endocrine disrupting chemicals (plastics, pesticides, herbicides, flame retardants, marijuana, opiates, other drugs of abuse) that your health and well being may depend on restoring your testosterone, stopping the things that are suppressing your pituitary, and eating whole foods rather than processed foods.


You can read the study here…



Dr. Paul


Autism Related Costs for the USA Projected to Approach 1 Trillion in the Next 10 Years

vaccine moneyShould you be worried about the rise in autism rates? YES! Does this evidence that something is wrong bother you? IT SHOULD! What are the costs to society associated with the increased rates of autism? THIS STUDY ANSWERS THIS QUESTION. If there is an increased rate of this magnitude, should we devote any money into figuring out why we are seeing this? ABSOLUTELY! Why can’t we seem to figure out why we are seeing so much chronic illness in today’s children (and adults)? MONEY & POLITICS.

In the study, “Brief Report: Forecasting the Economic Burden of Autism in 2015 and 2025 in the United States,” published in the Journal of Autism and Developmental Disorders, July 2015, authors “forecast annual direct medical, direct non-medical, and productivity costs combined will be $268 billion for 2015 and $461 billion for 2025.” They point out that this is similar to the expenses estimated for ADHD, and was a conservative estimate. You can read the study here…

The health of our nation is in deep trouble. The causes are right in front of us, but the establishment we have placed as caretakers of our health (CDC, Pharma, Government) are clearly unable to muster the will to break it down and devote the research dollars and design the studies that will provide the answers. This is not rocket science folks. When your population is suffering like this, you simply need to look at what you are doing to that population.

No, this is not an infectious disease epidemic. Yet so much of our research and CDC money goes to infectious disease studies, management, and research and development of vaccines and medication to treat infections rather than finding the real reason we are in trouble.

No, it’s not a genetic epidemic, our genetics are not going to change in a generation. At least not the genetics you think of when you hear the word genetics. What is changing is the epigenetic response to the environment. Hence what is destroying the health of our children, causing autism and ADHD and so much more, is the environment. I’m not an environmental activist. I do care about what we are doing to the environment. What I am is a very frustrated pediatrician, who started his career at the tail end of the infectious disease era, and the beginning of the chronic disease era. I see an outdated model of medicine being applied to a health situation as if the health condition were an infection.

When we had an infection, all we needed to do was identify it, and treat. We have done a masterful job of that and some of our vaccines helped along the way also. When you have a chronic disease like autism or ADHD (heart disease, stroke, diabetes, obesity etc.) and you try that same model of a vaccine or a pill to treat what has developed over years or decades due to poor nutrition and toxic exposures, you end up trying to treat a complex whole body metabolic disaster with a Band-Aid.

Our nation needs to get back to eating real food, whole food (not packaged) organically produced not GMO or pesticide sprayed, and drink filtered clean water, not from a plastic bottle. We then must stop injecting toxins, especially in the womb. The latest experiment on our pregnant moms of injecting a huge dose of aluminum with the Tdap, while pregnant, every pregnancy is nationwide poisoning with the end goal to hopefully reduce the 10-20 infant deaths that occur from pertussis out of the almost 4 million births each year in America. Our CDC has lost it’s way, if they can allow such human experimentation with no prior studies done on pregnant animals even that injected that much aluminum and followed the off-spring until they were teenagers. The rest of the infant vaccine schedule goes on to load up a whole lot more aluminum.

We have mounting evidence (studies) showing aluminum in vaccines is triggering auto-immune disorders. A new name ASIA (auto-immune disorders associated with adjuvants). You can learn more about ASIA here…   All we need is the will to look at what we are doing. Obviously we are doing something very wrong! Norway had an autism rate of 1 in 1000 while ours was 1 in 100 just a few years ago.

We must look at the obvious. I vaccinate every day, all day long, in my office, but selectively in a way that will hopefully provide protection without damaging my patients. We need to look long-term at the outcomes of non-vaccinated, partially vaccinated, and fully vaccinated children. We need to look long-term at the outcomes for those who get a new vaccine. We need to look long-term at the outcomes every time the CDC adds a vaccine to the schedule, as it then becomes a whole new experiment. So far the experiment is not going well.

We MUST immediately stop the poisoning of every unborn child in the USA with the Tdap. This simply cannot be allowed to continue or our health costs will be in the trillions and our country will be brought to its knees in another decade or two. We likewise must stop the insanity of injecting aluminum into newborns and infants with the Hepatitis B vaccine unless birth mom has Hepatitis B.

Do not fall for the lie that “vaccines are safe and effective”. Some are and some aren’t.  It would be like saying you should take all antibiotics. It’s all about timing and looking at long term side effects.


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Dr. Paul




How Long Does it Take for a Blood Culture to Turn Positive in a Septic or Bacteremic Infant? Study Answers the Question

baby_cutieSince the age of the dinosaurs (ok the last 30 years) we have been observing sick infants (typically those under 2 months who have a fever) in the hospital after drawing blood cultures, cerebral spinal fluid, urine, getting a chest X-ray (CXR) and putting them on antibiotics for a minimum of 48 hours. This is what in doctor speak was a “septic work-up”. Think of it as insurance because if we didn’t do this, it could be your child that actually has the potentially fatal infection. What we know is that a percentage of these infants would have died of overwhelming infection if left untreated. That percentage is relatively low. Depending on how sick they look and other variables, it could be as low as 2% or in the very ill infant, obviously much higher.

The standard has always been that you keep these infants on IV antibiotics for at least 48 hours while you wait for the blood culture results. The study, “Blood culture time to positivity in febrile infants with bacteremia,” (which you can read here… ) looked at almost 400 positive blood cultures in infants under 90 days of age and found that 91% were positive by 24 hours, 96% by 36 hours and 99% by 48 hours. The authors conclude “inpatient observation of febrile infants for more than 24 hours may be unnecessary in most infants.”

Since these are the sickest of sick infants, most at risk of overwhelming infection, I would make a different conclusion, which is that the 48 hour observation time on antibiotics is perfect as it will pick up 99% of those infants who needed to be on antibiotics. Sending infants home after 24 hours would miss 9% of the sickest infants, potentially sending them home to end up with overwhelming infection. Now the truth is that the 24 hours of antibiotics may have actually been enough to kill the bacteria and those 9% might end up fine anyway. That is the topic of a yet to be done study, that we likely can never do as it would not be ethical to put a group of infected infants on the untreated arm of the study just to see if they were cured by one day of antibiotics.

So for now, I recommend we stay with the 48 hours sepsis work-up. There is a simple and likely very effective compromise. We have a very effective antibiotic that has the ability to be dosed once a day due to its very long half-life; ceftriaxone. Infants with negative blood cultures at 24 hours, could be given a dose of ceftriaxone and then seen in a day. This won’t cover the very rare cases of sepsis and bacteremia from the organism listeria, but would cover most other causes of infection in this age group.

Consult with your physician of course. This blog is not meant to change standard of care, merely passing on interesting information.



Dr. Paul



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