Vitamin D Reduces Inflammation and Intestinal Permeability in Crohn’s Disease

VitaminD-Sun   The study, “Effects of vitamin D supplementation on intestinal permeability, cathelicidin and disease markers in Crohn’s disease:  Results from  a randomized double-blind placebo-controlled study,” looked at intestinal permeability, plasma cathelicidin (LL-37 in ng/mL), human-beta-defensin-2 (hBD2 in pg/mL), disease activity (Crohn’s Disease Activity Index (CDAI)), C-reactive protein (CRP in mg/L), fecal calprotectin (µg/g), Quality of Life (QoL) and serum 25-hydroxyvitamin D (25(OH)D in nmol/L) at 0 and 3 mos. You can read the study by clicking here…  In a double blinded, placebo controlled study, participants with Crohn’s were randomized to get 2000 IU vitamin D3 or placebo.

Those on the vitamin D (2000 IU daily is a very low dose in my opinion, I recommend 5000 IU daily for adults) had significantly higher vitamin D levels, improved intestinal permeability, increased cathelicidin (important for the immune system), reduced CRP (inflammation), and improved quality of life scores.

I recommend everyone, yes everyone on earth (except perhaps those working shirtless in the sun all day) take extra vitamin D. The benefits to your health and immune system are documented beyond a shadow of a doubt. You will have less heart disease, stroke, cancer, immune disorder, calcium deficiencies, and the list goes on and on. If I could only take one supplement, it should be vitamin D.

Start with 1000 IU for newborns. By the time your child is 20 Kg (40 lbs), give them 2000 IU daily. Teenagers and adults can take 5000 IU daily. If you want to be sure this recommendation is working for you, and just in case you are somehow getting more than you need on this dosing,  get your level checked after 3- 6 months of daily supplementing.  If you have had your level checked and you are very low (vitamin D level less than 30 ng/ml) you can take a one time loading dose of vitamin D that is 10 times the daily dose I have suggested above.


For reference: See here…


Serum 25-Hydroxyvitamin D [25(OH)D] Concentrations and Health* [1]
nmol/L** ng/mL* Health status
<30 <12 Associated with vitamin D deficiency, leading to rickets in infants and children and osteomalacia in adults
30–50 12–20 Generally considered inadequate for bone and overall health in healthy individuals
≥50 ≥20 Generally considered adequate for bone and overall health in healthy individuals
>125 >50 Emerging evidence links potential adverse effects to such high levels, particularly >150 nmol/L (>60 ng/mL)

* Serum concentrations of 25(OH)D are reported in both nanomoles per liter (nmol/L) and nanograms per milliliter (ng/mL).
** 1 nmol/L = 0.4 ng/mL



Dr. Paul


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