Biploar, Glutamatergic Synapses and ANK3 Genes

genetics2The article “Psychiatric risk factor ANK3/Ankyrin-G nonodomains regulate the structure and function of glutamatergic synapsis,” is a mouth-full to say the least.  Here’s the message:

  • ANK3 gene codes for the protein ankyrin-G has an important role in psychiatric disorders, especially bipolar disorder, but also autism and schizophrenia.
  • With super resolution imaging they identified that ankyrin-G acts near the synapse regulating structure and function of gabamatergic synapses.


Neuronal activity promotes ankyrin-G accumulation where it regulates NMDA receptor-dependent plasticity.  This sounded important, but how we can change our diet, nutrients, toxin exposure, etc. to improve our GABA function in the face of these risk factors remains to be seen. I’m sure the pharmaceutical companies will try to find a way to help us using this information.

You can read the study here…

Sorry – this one was for the super nerd scientists.


Dr. Paul





One comment

  • Aspienerdo

    ANK3 NM_020987 Genes are involved in autism spectrum disorders. This gene is specific to autism and epilepsy. When a clinical correlation is discovered in a patient, a doctor should also request a Genecept Assay Test to further aid in the treatment of this patient, given most patients with ANK3 variations show adverse reactions to antipsychotics and SSRIs. Medications like Lamictal, VItamin D, N-acetylcysteine are generally well tolerated in axis 3 (ANK3) patients, given comorbid factors. The worst drugs for anyone showing ANK3 variations are antipsychotics and excessive amounts of benzodiazepines, though PRN use of benzos does not seem to be contraindicated. There is an urgent need to interpret if the increase or decrease of the expression of ANK3 by any chemical agent is either helpful or harmful, because currently too many physicans are left in the dark on which pharmaceutical agents are actually hurting people with ANK3 mutations, even if it’s one allele.

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