Biploar, Glutamatergic Synapses and ANK3 Genes
The article “Psychiatric risk factor ANK3/Ankyrin-G nonodomains regulate the structure and function of glutamatergic synapsis,” is a mouth-full to say the least. Here’s the message:
- ANK3 gene codes for the protein ankyrin-G has an important role in psychiatric disorders, especially bipolar disorder, but also autism and schizophrenia.
- With super resolution imaging they identified that ankyrin-G acts near the synapse regulating structure and function of gabamatergic synapses.
Neuronal activity promotes ankyrin-G accumulation where it regulates NMDA receptor-dependent plasticity. This sounded important, but how we can change our diet, nutrients, toxin exposure, etc. to improve our GABA function in the face of these risk factors remains to be seen. I’m sure the pharmaceutical companies will try to find a way to help us using this information.
You can read the study here…
Sorry – this one was for the super nerd scientists.