Type 2 Diabetes Risk Based on Genetic SNP’s, Methylation Related Risk
When you hear that something is genetic, does your mind think, “then I’m doomed, there is nothing I can do about it?” I recommend you change your first thought to this, “genetic means epigenetic, so there must be some changes I can make to avoid this disorder, disease, or condition”.
This study measured almost half a million CpG sites in human pancreatic islets and identified 1,649 CpG sites and 853 genes where there was a difference in DNA methylation in the Type 2 diabetics (T2D) when compared to non-T2D controls. They go on to list some of these better known loci (areas/ sites) like TCF7L2, FTO, KCNQ1, and for altered gene expression, CDKN1A, PDE7B, SEPT9, and EXOC3L2. The study provides this detailed map of the methylome (new word for me that I suspect means the methylation genome) in the human pancreatic islets and concludes that altered DNA methylation in human islets contributes to perturbed hormone secretion and the pathogenesis of Type 2 Diabetes.
TAKE HOME POINT:
Since methylation seems to be critical for most “genetic”, meaning epigenetic, issues, you should support your methylation cycle. This requires many vitamins with B2, B3, B6, methyl-folate, and methyl-B12 being most important. If you want to be sure you are getting these key nutrients into the cells (that’s where you need them), consider having your blood tested here using Spectracell Micronutrient Testing (MNT). This is a test I have done for over 10 years in my pediatrics practice (www.drpaul.md) and I am now offering for adults at Natura (www.naturaintegrativemedicine.com).
You can read more about this study here…