MTHFR Enzyme Defect: What Is It and How To Overcome It?

Methylation2MTHFR stands for Methylenetetrahydrofolate Reductase.  This enzyme is responsible for the conversion of 5,10–methylene tetra-hydro-folate to 5 methy-tetrahydrofolate. The
5-methyltetrahydrofolate then joins with MS (methionine synthase) and vitamin B-12 and takes homocysteine to cysteine.

OK, too many big words.  Bottom line is this:  40% of Americans are at least carriers of this defect with reduced activity that puts you at risk for:

  • Most chronic diseases.
  • High homocysteine with related Heart Attacks, Stroke and Heart Disease.
  • ADD, ADHD, Bipolar, Depression, Anxiety, and most psychiatric or mood and mental disorders.
  • Fatigue, fibromyalgia.
  • Tongue issues, fingernails and skin problems, and thin hair.
  • Varicose veins, Spider veins.
  • Acne fibroids, endometriosis, menstrual issues.
  • Altered detox pathways (elevated ammonia and uric acid).
  • Gut barrier dysbiosis.
  • Hormone imbalances, fertility issues, PCOS, testosterone imbalance.
  • Intolerance of medications and alcohol.
  • Cancers.
  • Estrogen dominance, hyper-insulin.
  • Autoimmunity disorders.


What can you do?  If you are my patient, come in for micronutrient testing and MTHFR testing (Children at  and adults at

Because we live in a much more toxic world, and the methylation cycle (MTHFR key in that cycle) is critical for our ability to get rid of toxins, I suspect that every living person on this planet would benefit from support of the methylation cycle.  We do this by supplementing or taking adequate B2, B3, methyl-B6, methyl-B12, Magnesium, NAC. Ceralin Forte from Metagenics, available at my office or click on the link on my website for my discount through Emerson Ecologics ( contains the right methyl-B6 and B12, along with NAC, B3, and Carnitine.  I you were to take one thing, this should be it.  

Obviously, avoiding ongoing toxins (by eating organic and drinking filtered water) and knowing exactly what nutrients you personally need is best.                                              

To your health and wellness 


Dr. Paul



  • Tanya Long

    I just received results that my 3 year old son and I are C677T homozygous ( I also suspect my 18 month old ). I was interested in trying the ceralin forte but I’m still nursing my 18 month old (down to just 1 nursing/day)… Do you think it would be okay to take the ceralin forte?

  • yes – should be totally fine and probably a good idea for you to take ceralin forte while nursing and forever more

  • Tanya Long

    Thank you so much for your response. Would you recommend giving this to a three-year-old as well? If so what dosage would you recommend?

  • Christina Giunta

    Dr. Thomas — where are you located? I am in Illinois. We just learned that our son is homozygous C677T and I am compound heterozygous C677T / A1298C. I understand mine is worse. My son is 15 and a couple of years ago he developed a testicular varicocele and I have spider veins that I have had since I was a teenager (I am now 50). I am learning that both of these can be from this mutation. Will supplementing with Methyl Folate help reverse / heal these? Thanks so much!

  • sorry for the late response – just stumbled on this. I’m not sure on reversing but sure worth a try. I take methyl-folate and methyl-B12 daily and will fo rthe rest of my life.

  • kenneth

    Thank you Dr. Paul, you and your son Noah have helped me a lot. You guys have a great bond!

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