MTHFR Enzyme Defect: What Is It and How To Overcome It?
MTHFR stands for Methylenetetrahydrofolate Reductase. This enzyme is responsible for the conversion of 5,10–methylene tetra-hydro-folate to 5 methy-tetrahydrofolate. The
5-methyltetrahydrofolate then joins with MS (methionine synthase) and vitamin B-12 and takes homocysteine to cysteine.
OK, too many big words. Bottom line is this: 40% of Americans are at least carriers of this defect with reduced activity that puts you at risk for:
- Most chronic diseases.
- High homocysteine with related Heart Attacks, Stroke and Heart Disease.
- ADD, ADHD, Bipolar, Depression, Anxiety, and most psychiatric or mood and mental disorders.
- Fatigue, fibromyalgia.
- Tongue issues, fingernails and skin problems, and thin hair.
- Varicose veins, Spider veins.
- Acne fibroids, endometriosis, menstrual issues.
- Altered detox pathways (elevated ammonia and uric acid).
- Gut barrier dysbiosis.
- Hormone imbalances, fertility issues, PCOS, testosterone imbalance.
- Intolerance of medications and alcohol.
- Estrogen dominance, hyper-insulin.
- Autoimmunity disorders.
Because we live in a much more toxic world, and the methylation cycle (MTHFR key in that cycle) is critical for our ability to get rid of toxins, I suspect that every living person on this planet would benefit from support of the methylation cycle. We do this by supplementing or taking adequate B2, B3, methyl-B6, methyl-B12, Magnesium, NAC. Ceralin Forte from Metagenics, available at my office or click on the link on my website for my discount through Emerson Ecologics (http://www.drpaul.md/onlinestore.htm) contains the right methyl-B6 and B12, along with NAC, B3, and Carnitine. I you were to take one thing, this should be it.
Obviously, avoiding ongoing toxins (by eating organic and drinking filtered water) and knowing exactly what nutrients you personally need is best.
To your health and wellness