Hepatitis B Vaccination of Newborns: Vital if Mom has Hepatitis B, Mistake if She Doesn’t

hep b2The major mechanism by which Hepatitis B is transmitted in the world is from mother to her newborn baby. The landmark study in 1975 in the NEJM found that at birth, only 5% of babies born to Hepatitis B positive moms had the virus, but by 3 months age 40% were positive for the virus. The prevalence of Hepatitis B is over 10% in parts of Asia and less than 1% in the USA. 

It is known that 240 million people in the world have Hepatitis B and that 600,000 die every year as a result of this infection.  Liver cancer is the most common cause of death and has been linked directly to the Hepatitis B viral infection.  The article “Decreased Incidence of Hepatocellular Carcinoma in Hepatitis B Vaccinees: a 20-year follow-up study” [link] showed a 70% decreased incidence for those who got the Hepatitis B vaccine at birth when their birth mom was a carrier or infected with the Hepatitis B virus.

I am 100% in support of the Hepatitis B vaccine for newborns if birth mom has Hepatitis B or might have Hepatitis B.  You might ask, why not just give everyone the Hepatitis B vaccine if it is as protective as you have just mentioned?  If I practiced in parts of the world where Hepatitis B rates were high, and especially if the mothers at delivery had unknown Hepatitis B status, I most certainly would be in favor of giving the vaccine to each of those newborns. The main way one catches hepatitis B other than from their mother at birth, is through sex and IV drug use (blood products). I’m quite certain that the risk to babies of them having sex or sharing needles is zero.  If birth mom knows she does not have hepatitis B (either she is known to be immune from vaccines, or she has been tested and knows she is negative for Hepatitis B) then why would such a parent choose to increase the risk of her baby getting autism by 300%?

Giving the Hepatitis B vaccine with its 250 micrograms of aluminum, a known neurotoxin, does just that! The Journal of Toxicology Environmental Health article “Hepatitis B Vaccination of Male Neonates and Autism Diagnosis”, NHIS 1997-2002 from 2010 found that for the years 1997-2002, boys vaccinated as neonates had threefold (300%) greater odds for autism diagnosis compared to boys never vaccinated or vaccinated after the first month of life. 

Parents, you need to get the whole story.  Sadly, most physicians learn partial truths, quote good studies that only give part of the picture.  The time is now for common sense, and at least in countries like the USA where the prevalence of Hepatitis B is very low and most pregnant moms are tested and know their status with regards to Hepatitis B, for us to stop the indiscriminate poisoning of every newborn with the Hepatitis B vaccine and its high aluminum content.  

Thought for the day:  If the 250 micrograms of aluminum in the Hepatitis B vaccine given to newborns raises the autism rate for boys by 300%, how bad do you think giving the Tdap and it’s 330 micrograms of aluminum will be for the unborn children being exposed to this starting at 20 weeks gestational age?

Vertical transmission of hepatitis B antigen in Taiwan.

Decreased incidence of Hepatocellular carcinoma in hepatitis B Vaccinees: a 20-year follow-up study.

Hepatitis B vaccination of male neonates and autism diagnosis, NHIS 1997-2002

 

Dr. Paul

 

 

 

Parasites Can Help You Avoid Autoimmune Diseases like Diabetes, Lupus, RA, and more

parasitesThis study found that worms (helminths) induced a type 2 immune response with T helper cells and increased cytokines interleukin-4 (IL-4) and IL-3. These responses help control inflammation, and enhance tissue repair. 

This further supports the hygiene hypothesis that we have less autoimmune and improved immune function if we are living in a less hygienic and sterile environment. I’m not proposing we go out and intentionally get parasitic infections, but we might consider not treating some of the parasites that are found and known not to cause human illness. There may be opportunities in the near future for use of this information to reduce the major shift that has occurred in our modern world to the inflammatory type-1 immune response, leading to more allergies and autoimmune issues.

Read the Study Here

 

Paul / Dr. Paul

Methylation and Autism

twinsThis article in Molecular Psychiatry is impressive in scope, details, and importance (see link below).

This is the first systemic epigenomic analyses of monozygotic (MZ) twins (genetically identical) who are discordant (one has and one doesn’t have) for autism.  It shows the role of altered DNA methylation in autism. 

I’m reminded of the magnitude of the importance of the JAMA Feb 13th 2013 article on prenatal folate and autism rates in Norway, which showed an autism rate of 1 in 500 in moms who did not take folate and 1 in 1000 in moms who did.  Folate and vitamin B-12 are the key to the methylation cycle that provides the all important methyl groups needed for the methylation that is discussed in this article.

Even though there is a high genetic predisposition for autism (last year published at 23% chance of having a subsequent autism child if you have one), the cause is not a direct hard-wired genetic one as in down syndrome (trisomy 21).  This study, due to the considerable variability in symptoms of these concordant MZ twins, shows the cause is epigenetic, meaning it is environmental, how the environment affects methylation of the genes.  This is very important for parents to understand, because if the methylation can be repaired, there can be recovery, and there certainly can be significant reductions in future risks to other unborn children.

Epigenetic, meaning reversible changes of gene expression, independent of your DNA sequence, has been associated with brain development, drug addiction, autism spectrum, and other neuropsychiatric disorders, including psychosis, Rett syndrome, and Fragile-X. Epigenetic mechanisms have also been implicated for type 1 diabetes which doesn’t surprise me one bit.  

The hard core scientists among you will need to read the entire study design.  

Results of this study show that Autism Spectrum Disorders are not associated with global differences in DNA methylation but rather specific DMR gene regions.  Some of these were previously noted in the literature including: GABRB3AFF2NLGN2,JMJD1CSNRPNSNURFUBE3A and KCNJ10.

The top-ranked DMR located in the promoter region of PIK3C3 (cg19837131) was significantly hypomethylated in affected individuals compared with their unaffected co-twins”

“Given the known gender difference in DNA methylation across the X chromosome, these analyses were restricted to probes on the autosomes (N=22 678) to minimize gender-induced biases.”

 

The results of this impressive study show:

“1. Supports the association of variable DNA methylation with phenotypic differences between genetically identical individuals

2.  The observed DNA methylation differences in MZ twins discordant for ASD and ASD-related traits, who are otherwise matched for genotype, shared environment, age, sex, and other potential confounders, highlight the role of non-shared environmental and stochastic factors in the etiology of autism. These findings concur with mounting data suggesting that environmentally mediated effects on the epigenome may be relatively common and important for disease.

3.  Although DNA methylation at some CpG sites is consistently altered across the entire set of discordant twins, differences at other CpG sites are specific to certain symptom groups… significant genetic heterogeneity between the three core symptoms of ASD

4.  Considerable familial heterogeneity, with rare epigenetic alterations of large magnitude being potentially associated with ASD

5.  Significant correlations between DNA methylation and autism symptom scores across our sample cohort suggest that there is a quantitative relationship between the severity of the autistic phenotype and epigenetic variation at certain loci. This reinforces the view of autism as the quantitative extreme of a phenotypic spectrum and highlights the potential use of epigenetic biomarkers as a predictor for severity of symptoms

6.  in addition to implicating a number of novel genes in the etiology of ASD, we identified ASD-associated differential DNA methylation in the vicinity of multiple loci previously implicated in the pathogenesis of autism in genetic studies, including AFF2AUTS2GABRB3NLGN3NRXN1SLC6A4 andUBE3A (see Supplementary Table 12 for a comprehensive list)”

Take home message: avoid toxins that could harm your methylation cycle (heavy metals, pesticides, plastics) and take your Vitamin B-12, folate, and D.  Vitamin C and E will help in keeping you toxin free. Best way to stay toxin free is an organic diet heavy on fruits and vegetables prepared at home. Keep your GI track in tip top shape as it’s the main barrier to toxins that would otherwise disrupt your methylation.  If you are already struggling with GI issues, consider comprehensive digestive stool analysis, food sensitivity testing, and then either the GAPS diet or targeted interventions based on the findings of those tests. If you have any health challenges, particularly that involve brain function in any way, it would be best to assume you have gut issues.

Read the Study Here

Dr. Paul

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