Drugs That Increase Your Risk of B-12 Deficiency

antacidsB-12 deficiency results in so much disability and suffering, from psychiatric symptoms of depression, anxiety, and fatigue to neurological symptoms of headache, seizure, developmental delays in children, confusion and dementia in adults, to muscular weakness and unusual sensations in hands and feet, to clotting disorders, intestinal issues like GERD, indigestion, diarrhea or constipation, and to weakness and anemia. Since proper function of B-12 requires two steps involving the stomach (adequate acid, and intrinsic factor) it’s no surprise that most of the medications to treat GERD or stomach issues, acid reflux, etc., will interfere with B-12 and cause you to be deficient. 

You may be deficient in B-12 if you take any of the following medications:

PPI’s (Proton Pump Inhibitors): Prevacid, Prilosec, Protonix, Nexium, Acipex, Omperazole

H2 Blockers: Zantac, Tagamet, Axid, Pepcid

Antacids: Maalox, Mylanta, Tums, Alternagel, Riopan

Diabetes medications: Metformin, Glucophage, Riomet, Fortamet, Glumetza, Obimet, Dianben, Diabex, Diaformin, Glucovance

Potassium supplements: K-Lor, K-lyte, Klotix, K-Dur, Micro-K, Slow-K, Potasium Chloride

Gout medication: Colchicine

Questran for elevated cholesterol

Neomycin and para-aminosalicylic acid 

Dr. Paul


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