Genetics and Psychiatry Disorders

frogJust published Feb 28th, 2013 in Lancet, a very large study on genomics and looking for SNP’s (single-nucleotide poly-morphisms) that relate to the “Psychiatric Genomics Consortium: autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia”.

What you will read is that it’s your genetics that make you the way you are.  What you won’t read is that it’s the toxins in your world and your nutrient deficiencies that make you ill.  Regardless of your genetics, if not exposed to the toxin, you would be absolutely fine. 

Note that Autism Spectrum and ADHD are included and lumped with bipolar, major depression, and schizophrenia.  I actually think there is a shared risk for these disorders.  The risk has to do with our genetic vulnerability to toxins. It is the SNP’s that will be primarily identified in relation to toxins as it is in these areas of our genetic code that we are able to adjust to the environmental toxins.  Where most of medicine and psychiatry is missing the boat is that while they will identify hundreds if not thousands of SNP’s that have links to this and that disorder and these and those disorders, what is needed is to determine for those individuals WHICH TOXINS trigger the disorder or WHICH DEFICIENCIES set you up for vulnerability to the toxins. 

The conclusion after analysis of 33,000 and 27,000 cases and controls was as follows:

Our findings show that specific SNPs are associated with a range of psychiatric disorders of childhood onset or adult onset. In particular, variation in calcium-channel activity genes seems to have pleiotropic effects on psychopathology. These results provide evidence relevant to the goal of moving beyond descriptive syndromes in psychiatry, and towards a nosology informed by disease cause.

The goal it seems will be to label you not by symptoms (the mistake now made, instead of identifying which toxins are particularly harmful to you) but by your specific genetic SNP’s.  So I might be “3p21 and 10q24, and SNPs within two L-type voltage-gated calcium channel subunits, CACNA1C and CACNB2” and be autistic or ADHD, bipolar or schizophrenic, when in reality what I am is especially vulnerable to heavy metals, aspartame, pesticides, or uniquely deficient in vit D, or magnesium affecting my calcium channels.  The real cause is not your genetics; it’s your exposure to the toxins or your nutrient deficiencies that in the context of your specific genetics make you vulnerable. Let’s say I’m genetically vulnerable to becoming an alcoholic.  If I never drink alcohol will I ever be an alcoholic? One will never know.  It is this approach, that we must take when avoiding toxins and getting the right nutrition and nutrients.  I prefer not knowing what might have been, when we are talking about the kind of disorders described in this article.

Our government has allocated about 75% of the health research dollars to genetics and the connection of genetics with the environment (SNP) and about 5% to looking for the environmental causes of disease and illness. If I wish to get grant money to do research, it must fall into these specific areas to receive funding.

What is missed is that the real causes (the environmental toxins-what we are doing to ourselves through food, water, air, vaccines etc.) are not, and it seems will not be, studied.  We cannot find what we are not willing to look for!

Parents, never before was the need to be absolutely vigilant about what goes into your child’s body, starting from before you get pregnant. Moms on folate before they get pregnant have a 50% lower rate of autism. Developing brains are particularly vulnerable in the womb. So moms, please don’t get the Tdap with it’s 330 micrograms of aluminum while pregnant. Why would you inject 250 micrograms of aluminum into your unborn child?  

Vaccinate rationally. Don’t get tricked into giving the Hep B to your newborn, if mom is immune or does not have Hepatitis B. Hepatitis B is acquired through sex and IV drug use (blood borne pathogen).  The newborns in my practice so far have not been sexually active or sharing needles in the park.
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2812%2962129-1/fulltext

 

Dr. Paul

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