How many of us know the value of melatonin?  I have recommended it for years for those with difficulty sleeping.  Melatonin is a hormone our brains make naturally, with a rise in production as the sun goes down (lights go off) that results in a state of increased sleepiness.  It has also been known to be a great antioxidant, and indeed the study below shows a protective effect against aluminum.  Since there is way too much aluminum in many of the vaccines (Hep B, Hep A, Dtap, TDaP, Prevnar, HPV, and the PedVaxHib , pentacle and Pediarix), it makes sense to take melatonin before, during and for at least a couple weeks after your child receives one of the aluminum containing vaccines.


INFANTS: Could take 1/2 mg daily before during and for a few days after an aluminum containing vaccine is given. (Use of Melatonin has not been well tested in infants, therefore this is not a recommendation to do this.) 
PRESCHOOL:  1/2 to 1 mg at bed time.  
SCHOOL AGE:  1 – 2 mg at bed time.  
TEENS: 2 – 3 mg at bedtime. 

 While these recommendations are not your typical AAP guidelines, they use the best information available in the integrative medicine world with a splash of common sense and creative thinking given the information in the study below.

Remember, that in some cases the risks of injecting the aluminum with the vaccine must be weighed with the potential benefits of that vaccine.  My own interpretation is that the current recommendation to inject 170 – 650 micrograms with the Dtap to pregnant moms is too great a risk to the unborn child, when there have only been a handful of deaths in the first few months of life in the entire USA out of about 4 million births this past year. That is in the worst year for pertussis in the USA for over 50 years.  Unfortunately our ACIP (CDC) immunization practices committee members must not be aware of the risks posed by injecting aluminum.  I am drafting a letter to bring this issue to their attention, but in the mean time, make your best decision, or if you would like to know what I would do if it were my wife or daughter carrying a baby:  I would wait and give no aluminum vaccines while pregnant, and give mom, dad and all household members and caregivers the pertussis vaccine as soon as the baby was delivered. (If you have a strong family history of autism or severe neurological disorders, then it may be best to avoid the aluminum containing vaccines all together).

The baby can then get the DTaP at 2 months and the usual schedule and get adequate protection that way.


Here is a good study that shows the positive results of taking melatonin:


Aluminum-induced neurotoxicity and oxidative damage in rabbits: protective effect of melatonin.
Neuro Endocrinol Lett. 2005 Oct;26(5):609-16.

Abd-Elghaffar SKhEl-Sokkary GHSharkawy AA.

Department of Pathology and Clinical Pathology, Faculty of Science, Assiut University, Egypt.


The present study was aimed to investigate: (1) the neurotoxic oxidative damage of orally administered aluminum chloride (AlCl3) in rabbits (Biochemical and morphopathological studies). (2) The effect of melatonin as an antioxidant and free radical scavenger on oxidative neuropathic changes. Methods: Thirty-five male rabbits were divided into 4 groups (A, B, C [10 animals each] and D [5 animals]). Group A received AlCl3 (20 mg/l via drinking water for 3 months). Group B received AlCl3 for 3 months then administered with melatonin (10 mg/kg b.w. sc daily for 15 days). Group C received AlCl3 plus melatonin for 3 months. Group D received the solvent and served as control. Malondialdehyde (MDA) and 4-hydroxyalkenals (4-HDA) as lipid peroxides as well as superoxide dismutase (SOD) as an antioxidant enzyme were measured. Aluminum residue in the brain tissue was measured spectrophotometerically. The morphopathological changes were also examined by light and electron microscopes.


MDA and 4-HAD were significantly increased in group A versus those of controls while significantly decreased in groups B and C compared with those of A group. SOD run in an opposite manner. Aluminum concentration was significantly increased in groups A, B and C when compared with group D while it significantly decreased in groups B and C when compared with that of group A. The neuropathlogical examination in the animals of group A revealed atrophy and apoptosis of the neurons in cerebral cortex and hippocampus. This was associated with neurofibrillary degeneration as well as argyrophilic inclusion. Schwan cell degeneration and nerve fiber demylination were also encountered. The elaboration of lipid peroxidation products, inhibition of antioxidant enzymes and the morphopathological changes were minimized in the Al/Mel treated groups and markedly improved in Al+Mel treated group


Chronic aluminum exposure in rabbits had dramatic encephalopathic morphopathological lesions. It enhances the lipid peroxidation production and inhibits the SOD enzyme. Melatonin had a good prophylactic effect as an antioxidant in aluminum encephalopathy.


Dr. Paul

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