Vitamin C Deficiencies During Pregnancy

Future moms and pregnant moms: Please take your vitamin C.  

I would add that all moms take their prenatal with the folic acid and extra Vit D  up to 5000 IU  a day while pregnant. Here is an abstract that discusses the effects of not getting enough vitamin C during pregnancy and how that affects the brain. Please read below-

Dr Paul

Maternal Vitamin C Deficiency during Pregnancy Persistently Impairs Hippocampal Neurogenesis in Offspring of Guinea Pigs

Pernille Tveden-Nyborg1, Lucile Vogt2, Janne G. Schjoldager1, Natalie Jeannet2, Stine Hasselholt1, Maya D. Paidi1, Stephan Christen2,3#*, Jens Lykkesfeldt1#*
1 Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, 2 Institute of Infectious Diseases, University of Bern, Bern, Switzerland, 3 Department of Neurology, University of California San Francisco, San Francisco, California, United States of America

While having the highest vitamin C (VitC) concentrations in the body, specific functions of VitC in the brain have only recently been acknowledged. We have shown that postnatal VitC deficiency in guinea pigs causes impairment of hippocampal memory function and leads to 30% less neurons. This study investigates how prenatal VitC deficiency affects postnatal hippocampal development and if any such effect can be reversed by postnatal VitC repletion. Eighty pregnant Dunkin Hartley guinea pig dams were randomized into weight stratified groups receiving High (900 mg) or Low (100 mg) VitC per kg diet. Newborn pups (n = 157) were randomized into a total of four postnatal feeding regimens: High/High (Control); High/Low (Depleted), Low/Low (Deficient); and Low/High (Repleted). Proliferation and migration of newborn cells in the dentate gyrus was assessed by BrdU labeling and hippocampal volumes were determined by stereology. Prenatal VitC deficiency resulted in a significant reduction in postnatal hippocampal volume (P<0.001) which was not reversed by postnatal repletion. There was no difference in postnatal cellular proliferation and survival rates in the hippocampus between dietary groups, however, migration of newborn cells into the granular layer of the hippocampus dentate gyrus was significantly reduced in prenatally deficient animals (P<0.01). We conclude that a prenatal VitC deficiency in guinea pigs leads to persistent impairment of postnatal hippocampal development which is not alleviated by postnatal repletion. Our findings place attention on a yet unrecognized consequence of marginal VitC deficiency during pregnancy.

Citation: Tveden-Nyborg P, Vogt L, Schjoldager JG, Jeannet N, Hasselholt S, et al. (2012) Maternal Vitamin C Deficiency during Pregnancy Persistently Impairs Hippocampal Neurogenesis in Offspring of Guinea Pigs. PLoS ONE 7(10): e48488. doi:10.1371/journal.pone.0048488
Editor: Olivier Baud, Hôpital Robert Debré, France
Received: June 25, 2012; Accepted: September 25, 2012; Published: October 31, 2012
Copyright: © 2012 Tveden-Nyborg et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Funding: This study was supported by grants from the Danish National Research Council (#FSS271-08-0763) and the LIFEPHARM Centre in Denmark to JL and the Swiss National Science Foundation (310030_120725) to SC. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing interests: The authors have declared that no competing interests exist.


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